Investigators searching for answers in the disappearance of Nancy Guthrie have uncovered new forensic clues that could dramatically shift the direction of the case, including a trail of blood and DNA evidence now undergoing expedited testing.

Law enforcement sources say dried blood droplets were discovered leading from the front entrance of Guthrie’s home toward the driveway, suggesting a possible struggle or injury during the critical hours before she vanished. Authorities have not confirmed whose blood it is, leaving open the possibility that it could belong to Guthrie herself—or to an intruder.

The discovery has intensified fears that the 84-year-old mother of Today show co-anchor Savannah Guthrie may have been taken by force.

In parallel, multiple DNA samples collected from inside the residence have been sent to a forensic laboratory in Phoenix for urgent analysis. Officials hope the genetic material will help identify who was present in the home and whether any unknown individuals were involved.

“This type of forensic evidence can be pivotal,” a law enforcement source familiar with the investigation said. “Blood patterns and DNA can establish not just who was there, but what may have happened.”

The forensic findings add to a growing list of unsettling clues in the case, including suspicious digital data from Guthrie’s pacemaker, possible ransom communications, and a narrow timeline suggesting she vanished in the early morning hours. Investigators are working to reconstruct her last known movements and determine whether her disappearance was voluntary or criminal.

Authorities have not publicly named any suspects and caution against speculation as the DNA testing continues. In high-profile cases, officials often examine both family members and outside contacts as part of routine investigative protocol.

Experts say DNA results could either confirm benign explanations or open entirely new lines of inquiry. Even partial matches can help investigators map relationships, identify unknown visitors, or rule out certain scenarios.

As the search for Nancy Guthrie continues, the blood trail and DNA testing represent some of the most concrete physical evidence to emerge so far—offering hope that science may reveal what human witnesses could not.

And according to sources tracking the investigation, the first DNA profile is expected to be identified soon, potentially raising new questions about who was inside the home that night.